Intestinal ribosomal p70 signaling is increased in piglet rotavirus enteritis
نویسندگان
چکیده
J. Marc Rhoads, Benjamin A. Corl, Robert Harrell, Xiaomei Niu, Lori Gatlin, Oulayvanh Phillips, Anthony Blikslager, Adam Moeser, Guoyao Wu, and Jack Odle Department of Pediatrics, Ochsner Clinic Foundation and Ochsner Children’s Research Institute, New Orleans, Louisiana; Department of Animal Sciences and College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina; Faculty of Nutrition, Texas A&M University, College Station; and Department of Pediatrics, University of Texas, Houston, Texas
منابع مشابه
Arginine activates intestinal p70(S6k) and protein synthesis in piglet rotavirus enteritis.
We previously showed that phosphorylation of p70 S6 kinase (p70(S6k)) in the intestine is increased during viral enteritis. In this study, we hypothesized that during rotavirus infection, oral Arg, which stimulates p70(S6k) activation, will further stimulate intestinal protein synthesis and mucosal recovery, whereas the p70(S6k) inhibitor rapamycin (Rapa) will inhibit mucosal recovery. Newborn ...
متن کاملIntestinal ribosomal p70(S6K) signaling is increased in piglet rotavirus enteritis.
Recent identification of the mammalian target of rapamycin (mTOR) pathway as an amino acid-sensing mechanism that regulates protein synthesis led us to investigate its role in rotavirus diarrhea. We hypothesized that malnutrition would reduce the jejunal protein synthetic rate and mTOR signaling via its target, ribosomal p70 S6 kinase (p70(S6K)). Newborn piglets were artificially fed from birth...
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An early signaling event activated by amino acids and growth factors in many cell types is the phosphorylation of the mammalian target of rapamycin (mTOR; FRAP), which is functionally linked to ribosomal protein s6 kinase (p70(s6k)), a kinase that plays a critical regulatory role in the translation of mRNAs and protein synthesis. We previously showed that intestinal cell migration, the initial ...
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